Stem-loop mdv1-mir-M7

Accession

MI0005099

Description

Mareks disease virus type 1 mdv1-mir-M7 precursor miRNA

Sequence

ggagaacUGUUAUCUCGGGGAGAUCCCGAUcucuccuaccagcaacUCGAGAUCUCUACGAGAUUACAGuuuuugggggaaauguguccucagaacugcuuaaucguagaagcuuccuag
((((((((((.((((((.(((((((.(((...((......))....))).))))))).)))))).))))))((((((((.......)))))))).((((......))))....))))...

Structure

---    ------------------------------------------      U      G       C   -Ucu  cc 
   ggag                                          aacUGU AUCUCG GGAGAUC CGA    cu  u
   ||||                                          |||||| |||||| ||||||| |||    ||   
   ccuu                                          uuGACA UAGAGC UCUCUAG GCU    ga  a
gau    cgaagaugcuaauucgucaagacuccuguguaaaggggguuu      U      A       A   caac  cc 

Annotation confidence Not enough data

Comments

The identity of the dominant mature miRNA is inferred from next-generation sequencing reads [4], and differs from previous annotations in miRBase and in [1-3].

Genome context

AF243438.1: 142501-142620 [+]

Clustered miRNAs

3 other miRNAs are < 10 kb from mdv1-mir-M7

Mature mdv1-miR-M7-5p

• Accession: MIMAT0005804
• Description: Mareks disease virus type 1 mdv1-miR-M7-5p mature miRNA
• Sequence: 8 - UGUUAUCUCGGGGAGAUCCCGAU - 30
• Evidence: experimental ; cloned [2], Northern [2], Illumina [4]

Mature mdv1-miR-M7-3p

• Accession: MIMAT0003928
• Description: Mareks disease virus type 1 mdv1-miR-M7-3p mature miRNA
• Sequence: 47 - UCGAGAUCUCUACGAGAUUACAG - 69
• Evidence: experimental ; cloned [1,3], Northern [1], Illumina [4]

References

1. PubMed ID: 18256158
   MicroRNA profile of Marek's disease virus-transformed T-cell line MSB-1: predominance of virus-encoded microRNAs
   "Yao Y, Zhao Y, Xu H, Smith LP, Lawrie CH, Watson M, Nair V"
   "J Virol (2008) 82:4007-4015


2. PubMed ID: 16912324
   Marek's disease virus encodes MicroRNAs that map to meq and the latency-associated transcript
   "Burnside J, Bernberg E, Anderson A, Lu C, Meyers BC, Green PJ, Jain N, Isaacs G, Morgan RW"
   "J Virol (2006) 80:8778-8786


3. PubMed ID: 18430245
   Deep sequencing of chicken microRNAs
   Burnside J, Ouyang M, Anderson A, Bernberg E, Lu C, Meyers BC, Green PJ, Markis M, Isaacs G, Huang E, Morgan RW
   BMC Genomics (2008) 9:185


4. PubMed ID: 18842708
   Sequence conservation and differential expression of Marek's disease virus microRNAs
   "Morgan R, Anderson A, Bernberg E, Kamboj S, Huang E, Lagasse G, Isaacs G, Parcells M, Meyers BC, Green PJ, Burnside J"
   "J Virol (2008) 82:12213-12220