Stem-loop sme-let-7b

Accession

MI0005123

Description

Schmidtea mediterranea sme-let-7b precursor miRNA

Literature search

4 open access papers mention sme-let-7b
(16 sentences)

Sequence

581462 reads, 11928.0 reads per million, 28 experiments

guaacauuaacaauUGAGGUAGAUUGUUGGAUGACUUaauuuuaaagCCAUUCAACUAUCUGUCUUCUCUUGuuaaauuac
((((..(((((((..(((((((((.((((((((.(((.......))).)))))))).))))).))))..))))))).))))

Structure

    ca       uU    -     U        A   aa 
guaa  uuaacaa  GAGG UAGAU GUUGGAUG CUU  u
||||  |||||||  |||| ||||| |||||||| |||  u
cauu  aauuGUU  CUUC GUCUA CAACUUAC gaa  u
    -a       CU    U     U        C   au 

Annotation confidence High

Genome context

gb|NNSW01001095.1|: 59957-60037 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from sme-let-7b

Mature sme-let-7b-5p

• Accession: MIMAT0003953
• Description: Schmidtea mediterranea sme-let-7b-5p mature miRNA
• Sequence: 15 - UGAGGUAGAUUGUUGGAUGACUU - 37
• Evidence: experimental ; cloned [1], Northern [1], 454 [2], Illumina [2]

Mature sme-let-7b-3p

• Accession: MIMAT0003954
• Description: Schmidtea mediterranea sme-let-7b-3p mature miRNA
• Sequence: 48 - CCAUUCAACUAUCUGUCUUCUCUUG - 72
• Evidence: experimental ; cloned [1], 454 [2], Illumina [2-3]

References

1. PubMed ID: 16849698
   MicroRNAs from the Planarian Schmidtea mediterranea: a model system for stem cell biology
   "Palakodeti D, Smielewska M, Graveley BR"
   "RNA (2006) 12:1640-1649


2. PubMed ID: 19564616
   High-resolution profiling and discovery of planarian small RNAs
   "Friedlander MR, Adamidi C, Han T, Lebedeva S, Isenbarger TA, Hirst M, Marra M, Nusbaum C, Lee WL, Jenkin JC, Sanchez Alvarado A, Kim JK, Rajewsky N"
   "Proc Natl Acad Sci U S A (2009) 106:11546-11551


3. PubMed ID: 19553344
   Deep sequencing identifies new and regulated microRNAs in Schmidtea mediterranea
   "Lu YC, Smielewska M, Palakodeti D, Lovci MT, Aigner S, Yeo GW, Graveley BR"
   "RNA (2009) 15:1483-1491