Stem-loop mmu-mir-741

Accession

MI0005205

Symbol

MGI: Mir741

Description

Mus musculus mmu-mir-741 precursor miRNA

Literature search

4 open access papers mention mmu-mir-741
(23 sentences)

Sequence

148730 reads, 2220 reads per million, 45 experiments

uugaucUACGUAGAUUGGUACCUAUCAUGuaaaucauguaagcaUGAGAGAUGCCAUUCUAUGUAGAuuaa
.(((((((((((((.(((((.((.((((((...........)))))).)).))))).))))))))))))).

Structure

u             U     C  A      aaau 
 ugaucUACGUAGA UGGUA CU UCAUGu    c
 ||||||||||||| ||||| || ||||||    a
 auuAGAUGUAUCU ACCGU GA AGUacg    u
a             U     A  G      aaug 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chrX: 66796805-66796875 [-]

Clustered miRNAs

6 other miRNAs are < 10 kb from mmu-mir-741

Mature mmu-miR-741-5p

• Accession: MIMAT0017262
• Description: Mus musculus mmu-miR-741-5p mature miRNA
• Sequence: 7 - UACGUAGAUUGGUACCUAUCAUG - 29
• Evidence: experimental ; Illumina [5]

Mature mmu-miR-741-3p

• Accession: MIMAT0004236
• Description: Mus musculus mmu-miR-741-3p mature miRNA
• Sequence: 45 - UGAGAGAUGCCAUUCUAUGUAGA - 67
• Evidence: experimental ; cloned [1-2], 454 [3], Illumina [4-5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16766679
   Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
   "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
   "Genes Dev (2006) 20:1732-1743


3. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


4. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


5. PubMed ID: 17989215
   RNA sequence analysis defines Dicer's role in mouse embryonic stem cells
   "Calabrese JM, Seila AC, Yeo GW, Sharp PA"
   "Proc Natl Acad Sci U S A (2007) 104:18097-18102