Accession
MI0000242
Symbol
HGNC:
MIR199A1
Description
Homo sapiens
hsa-mir-199a-1 precursor miRNA mir-199
Gene
family?
family?
RF00144;
mir-199
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR199A1 is a microRNA gene located on chromosome 19, which encodes for the mature miR-199a-3p, a non-coding RNA involved in post-transcriptional gene regulation [PMC3281082][PMC9177676[PMC9177676]. This microRNA was found to be significantly upregulated in response to a 48-hour Bb infection, as demonstrated by validation using the miR-VILO kit [PMC5279786]. Additionally, MIR199A1 is among the 10 microRNAs with the highest absolute amount in a given study, indicating its potential biological significance [PMC8010072]. Functional analysis suggests that MIR199A1 has inferred functional partners such as miR21 and miR155, and shares a domain with these microRNAs, which may be relevant for precision health applications [PMC9962339]. Moreover, MIR199A1 has been identified as one of several non-coding RNAs potentially associated with hypospadias among other DMR-associated genes [PMC9834259]. Its upregulation has also been observed in differentially expressed transcripts in tumors, suggesting its role in post-transcriptional regulation that may affect tumor differentiation [PMC7433108].
Literature search
378 open access papers mention hsa-mir-199a-1
(2681 sentences)
(2681 sentences)
Sequence
3282217
reads,
10221
reads per million, 150 experiments
gccaaCCCAGUGUUCAGACUACCUGUUCaggaggcucucaauguguACAGUAGUCUGCACAUUGGUUAggc
(((...(((((((.((((((((.(((.((.(((...)))..))...))))))))))).)))))))...)))
(((...(((((((.((((((((.(((.((.(((...)))..))...))))))))))).)))))))...)))
Structure
aaC U C --U -g g gcc CCAGUGU CAGACUAC UGU Ca gag ||| ||||||| |||||||| ||| || ||| c cgg GGUUACA GUCUGAUG ACA gu cuc AUU C - ugu aa u
Annotation confidence
High
Do you think this miRNA is real?
Comments
Lagos-Quintana et al. [1] cloned miR-199 from human osteoblast sarcoma cells. They also reported identification of a miRNA from the opposite arm in mouse cells. This sequence was named miR-199-s and the sequence from the 3' arm of the homologous mouse precursor miR-199-as. Lim et al. [2] independently predicted this miRNA computationally using conservation with mouse and Fugu rubripes sequences [2]. Expression of the miR excised from the 5' arm was validated in zebrafish, and the ends mapped by cloning. The excised miR sequences are renamed miR-199a (to avoid confusion with the subsequently identified miR-199b (MIR:MI0000282)) and miR-199a* (from the 3' arm) here. The two putative hairpin precursors in human map to chromosome 19 (mir-199a-1, MIR:MI0000242) and chromosome 1 (mir-199a-2, MIR:MI0000281). Landgraf et al. show that both mature products are expressed, prompting the renaming to miR-199a-5p and miR-199a-3p [4].
Genome context
chr19: 10817426-10817496 [-]
Disease association
hsa-mir-199a-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-199a-5p
| Accession | MIMAT0000231 |
| Description | Homo sapiens hsa-miR-199a-5p mature miRNA |
| Sequence | 6 - CCCAGUGUUCAGACUACCUGUUC - 28 |
| Evidence |
experimental
cloned [2-4] |
| Database links |
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| Predicted targets |
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Mature hsa-miR-199a-3p
| Accession | MIMAT0000232 |
| Description | Homo sapiens hsa-miR-199a-3p mature miRNA |
| Sequence | 47 - ACAGUAGUCUGCACAUUGGUUA - 68 |
| Evidence |
experimental
cloned [4], Illumina [5] |
| Database links |
|
| Predicted targets |
|
References
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