Accession
MI0000071
Symbol
HGNC:
MIR17
Description
Homo sapiens
hsa-mir-17 precursor miRNA mir-17
Gene
family?
family?
RF00051;
mir-17
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR17 is a microRNA that plays a significant role in the regulation of gene expression, impacting various biological processes [PMC8627999]. Research has demonstrated the potential of grapefruit-derived nanovectors to deliver therapeutic MIR17 to the brain, indicating a novel approach for treatment strategies [PMC8067521]. In plant studies, MIR17's importance is underscored by observations that double-knockdown lines involving MIR17 exhibit notable reductions in shoot surface area, suggesting its role in shoot growth regulation [PMC8528425]. However, while MIR17 is implicated in the control of STAT3 levels, it is not directly associated with the control of NF-KB1; instead, it is part of a complex gene regulatory network that includes other microRNAs and regulatory proteins such as BRCA1, which are involved in the regulation of STAT3 [PMC8627999].
Literature search
756 open access papers mention hsa-mir-17
(4318 sentences)
(4318 sentences)
Sequence
1978742
reads,
7181
reads per million, 159 experiments
gucagaauaauguCAAAGUGCUUACAGUGCAGGUAGugauaugugcaucuACUGCAGUGAAGGCACUUGUAGcauuauggugac
((((..(((((((..((((((((.((.(((((.(((((.......)).)))))))).)).))))))))...)))))))..))))
((((..(((((((..((((((((.((.(((((.(((((.......)).)))))))).)).))))))))...)))))))..))))
Structure
ga -CA A G G - au
guca auaaugu AAGUGCUU CA UGCAG UAG ug a
|||| ||||||| |||||||| || ||||| ||| || u
cagu uauuacG UUCACGGA GU ACGUC Auc ac g
gg AUG A G - u gu
Annotation confidence
Medium
Do you think this miRNA is real?
Genome context
chr13: 91350605-91350688 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-17
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-17 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-17 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-17 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-17-5p
| Accession | MIMAT0000070 |
| Description | Homo sapiens hsa-miR-17-5p mature miRNA |
| Sequence | 14 - CAAAGUGCUUACAGUGCAGGUAG - 36 |
| Evidence |
experimental
cloned [2,5-8], Northern [4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-17-3p
| Accession | MIMAT0000071 |
| Description | Homo sapiens hsa-miR-17-3p mature miRNA |
| Sequence | 51 - ACUGCAGUGAAGGCACUUGUAG - 72 |
| Evidence |
experimental
cloned [1,5,7-8], Northern [1] |
| Database links |
|
| Predicted targets |
|
References
|
