Accession
MI0000298
Symbol
HGNC:
MIR221
Description
Homo sapiens
hsa-mir-221 precursor miRNA mir-221
Gene
family?
family?
RF00651;
mir-221
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR221 is a microRNA that has been studied in various contexts [PMC7318537]. Annexin V analysis showed significantly more apoptotic cells among cells transfected with the MIR221 inhibitor than among those transfected with the MIR221 mimics [PMC7318537]. In LX2 cells, the overexpression of MIR221 mimics resulted in the aggregation of P62, indicating autolysosome dysfunction [PMC8436230]. The effects of GATA4-Exo, the MIR221 inhibitor, and PTEN deletion on p-Akt and c-Cas-3 expression were tested after hypoxia stimulation [PMC7318537]. In a study analyzing microRNAs in hyperlipidemia-related diseases, including atherosclerosis, non-alcoholic fatty liver disease (NAFLD), obesity, and type II diabetes (T2DM), it was found that both miR155 and MIR221 were significantly modulated in all four diseases [PMC7604447]. Several miRNAs, including MIR21, MIR221, MIR222, MIR26, and MIR19 have been shown to function as oncomiRs by targeting PTEN expression and promoting cancer cell growth [PMC4389881]. The expression level of MIR221 was normalized to U6 RNA [PMC8327461]. Additionally, aberrant expression of miRNAs such as miR34, miR36, miR21, miR203 was observed in breast cancer along with upregulation of both MIR221 and MIR222. This upregulation correlated with downregulated p53 gene profile and activation of oncogenic pathways such as PI3K-Akt-mTOR signaling [PMC8071157].
Literature search
572 open access papers mention hsa-mir-221
(4115 sentences)
(4115 sentences)
Sequence
1352665
reads,
5088
reads per million, 157 experiments
ugaacauccaggucuggggcaugaACCUGGCAUACAAUGUAGAUUUcuguguucguuaggcaacAGCUACAUUGUCUGCUGGGUUUCaggcuaccuggaaacauguucuc
.((((((((((((....(((.(((((((((((.(((((((((....(((((((.....))).))))))))))))).))))))).)))).))))))))))....)))))..
.((((((((((((....(((.(((((((((((.(((((((((....(((((((.....))).))))))))))))).))))))).)))).))))))))))....)))))..
Structure
-u ---- cugg a - U AUUU - c gaaca uccaggu ggc ugaA CCUGGCA ACAAUGUAG cugu guu g ||||| ||||||| ||| |||| ||||||| ||||||||| |||| ||| u cuugu aggucca ucg aCUU GGGUCGU UGUUACAUC GAca cgg u cu acaa ---- g U C ---- a a
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and later validated in human HL-60 leukemia cells [2].
Genome context
chrX: 45746157-45746266 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-221
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-221 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-221-5p
| Accession | MIMAT0004568 |
| Description | Homo sapiens hsa-miR-221-5p mature miRNA |
| Sequence | 25 - ACCUGGCAUACAAUGUAGAUUU - 46 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-221-3p
| Accession | MIMAT0000278 |
| Description | Homo sapiens hsa-miR-221-3p mature miRNA |
| Sequence | 65 - AGCUACAUUGUCUGCUGGGUUUC - 87 |
| Evidence |
experimental
cloned [2-4], Illumina [5] |
| Database links |
|
| Predicted targets |
|
References
|
